It is used extensively in type 2ĭiabetics particularly in overweight patients. This has been successfully used for almost five decadesīy clinicians all over the world. Metformin is a first-line oral antidiabetic agent as per These side effects may also occur even after prolonged treatment with metformin. So before extensive evaluation of any GI problem in patient on metformin, other methods can be tried like temporary discontinuation, dose titration or proper intake of medicine. On the basis of duration of therapy, most of patients had side effects during initial phase of treatment but some patients also presented after long duration of treatment.Ĭonclusion: Gastrointestinal side effects being most common side effect of metformin can lead to discontinuation of therapy. These side effects are diarrhea (33), nausea/vomiting (28), pain abdomen (23), flatulence (16), retching (13), dysgeusia (7). 62 (51.66%) patients presented with GI side effects. Mean duration of metformin therapy was 3 years (6 weeks to 6 years) & mean metformin dose was 1000mg (500 mg – 2500 mg).
![side effect of metformin side effect of metformin](https://i.ytimg.com/vi/7A7La9P4nVM/maxresdefault.jpg)
Results: Mean age of study group was 52.8☑1.9 years with mean weight 72.4☑0.3 kg. All patients were evaluated for gastrointestinal side effects. 120 type 2 diabetic patients were included after detailed history, physical examination & inclusion/exclusion criteria, who were on metformin tablet only, for variable duration. Methodology: This is a retrospective cross sectional study, conducted in tertiary care hospital at Kota.
![side effect of metformin side effect of metformin](https://i.ytimg.com/vi/wEqt0b05LFg/maxresdefault.jpg)
This study is to estimate metformin related GI side effects in Indian population. GI side effects of metformin are not so uncommon rather under reported or wrongly diagnosed as primary gastrointestinal disorder. Introduction: Digestive disorders represent the most common metformin related side-effects in type 2 diabetics.